Dr. Gabriel Frank
Dr. Frank is interested in establishing direct correlations between the biochemical states and the conformations of molecular machines while they perform their tasks. The main tools used in the Frank group are cryo-electron microscopy (cryo-EM), which enables structural determination of proteins in near-native conditions, and optical spectroscopy, which allows for the detection and characterization of ligands at the single molecule level. To achieve their goals, Dr. Frank and his team are developing strategies designed to combine the two experimental approaches for the detailed analysis of several scientifically and medically important molecular machines and enzymes:
- ABC exporters which translocate lipids, bile, and sterols across membranes, and contribute to multidrug resistance.
- Phospholipases that are modulated by bile.
- Membrane fusion machineries that mediates cell-cell fusion and viral infection.