Dr. Anat ShaharHead
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X-ray crystallography is the gold standard for determining biological structures at high resolution. Protein crystals are subjected to X-ray radiation, and the pattern of diffraction obtained is used to solve the structure of the molecule. X-ray crystallography thus provides vital information about structure-function relationships and protein-protein and protein-ligand interactions. The Macromolecular Crystallography Research Centre (MCRC) provides expert services needed for determining the three-dimensional structure of a protein. These services begin with protein crystallization and can continue through to crystal measurement and three-dimensional structural analysis. The MCRC also offers advanced robotics instrumentation to facilitate mass screening and imaging.
- Email: anshahar@bgu.ac.il
- Visit Website

Publications
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Sananes A., Cohen I., Shahar A., Hockla A., De Vita E., Miller A.K., Radisky E.S. and Papo N.(2018)
A potent, proteolysis-resistant inhibitor of kallikrein-related peptidase 6 (KLK6) for cancer therapy, developed by combinatorial engineering.
JBC. -
Zur Y., Rosenfeld L., Bakhman A., Ilic S., Hayun H., Shahar A., Akabayov B., Kosloff M., Levaot N. and Papo N. (2017)
Engineering a monomeric variant of macrophage colony-stimulating factor (M-CSF) that antagonizes the c-FMS receptor.
Biochemistry Journal 474(15):2601-2617. -
Vainer R., Cohen S., Shahar A., Zarivach R. and Arbely E. (2016)
Structural Basis for p53 Lys120-Acetylation-Dependent DNA-Binding Mode.
JMB 428(15):3013-3025. -
Kanteev M., Bregman-Cohen A., Deri B., Shahar A., Adir N. and Fishman A. (2015)
A crystal structure of 2-hydroxybiphenyl 3-monooxygenase with bound substrate provides insights into the enzymatic mechanism.
BiochimBiophysActa. 1854(12):1906-1913. -
Dror A., Kanteev M., Kagan I., Gihaz S., Shahar A. and Fishman A. (2015)
Structural insights into methanol-stable variants of lipase T6 from Geobacillusstearothermophilus.
Appl. Microbiol. Biotechnol. 99(22):9449-9461.